Cargando…

Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence

Reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions. Aging-regulating genes p66shc, Sirtuin, FOXO3a and Klotho are new important factors whic...

Descripción completa

Detalles Bibliográficos
Autor principal: Afanas'ev, Igor
Formato: Texto
Lenguaje:English
Publicado: Landes Bioscience 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952092/
https://www.ncbi.nlm.nih.gov/pubmed/20716932
http://dx.doi.org/10.4161/oxim.3.2.2
_version_ 1782187748083367936
author Afanas'ev, Igor
author_facet Afanas'ev, Igor
author_sort Afanas'ev, Igor
collection PubMed
description Reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions. Aging-regulating genes p66shc, Sirtuin, FOXO3a and Klotho are new important factors which are stimulated by ROS signaling. It has been shown that ROS participate in initiation and prolongation of gene-dependent aging development. ROS also participate in the activation of protein kinases Akt/PKB and extracellular signal-regulated kinase ERK, which by themselves or through gene activation stimulates or retards cell senescence. Different retarding/stimulating effects of ROS might depend on the nature of signaling species—superoxide or hydrogen peroxide. Importance of radical anion superoxide as a signaling molecule with “super-nucleophilic” properties points to the possibility of the use of superoxide scavengers (SOD mimetics, ubiquinones and flavonoids) for retarding the development of aging.
format Text
id pubmed-2952092
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-29520922011-03-01 Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence Afanas'ev, Igor Oxid Med Cell Longev Opinion Paper Reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions. Aging-regulating genes p66shc, Sirtuin, FOXO3a and Klotho are new important factors which are stimulated by ROS signaling. It has been shown that ROS participate in initiation and prolongation of gene-dependent aging development. ROS also participate in the activation of protein kinases Akt/PKB and extracellular signal-regulated kinase ERK, which by themselves or through gene activation stimulates or retards cell senescence. Different retarding/stimulating effects of ROS might depend on the nature of signaling species—superoxide or hydrogen peroxide. Importance of radical anion superoxide as a signaling molecule with “super-nucleophilic” properties points to the possibility of the use of superoxide scavengers (SOD mimetics, ubiquinones and flavonoids) for retarding the development of aging. Landes Bioscience 2010 /pmc/articles/PMC2952092/ /pubmed/20716932 http://dx.doi.org/10.4161/oxim.3.2.2 Text en Copyright © 2010 Landes Bioscience
spellingShingle Opinion Paper
Afanas'ev, Igor
Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
title Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
title_full Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
title_fullStr Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
title_full_unstemmed Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
title_short Reactive oxygen species and age-related genes p66Shc, sirtuin, FoxO3 and klotho in senescence
title_sort reactive oxygen species and age-related genes p66shc, sirtuin, foxo3 and klotho in senescence
topic Opinion Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952092/
https://www.ncbi.nlm.nih.gov/pubmed/20716932
http://dx.doi.org/10.4161/oxim.3.2.2
work_keys_str_mv AT afanasevigor reactiveoxygenspeciesandagerelatedgenesp66shcsirtuinfoxo3andklothoinsenescence