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Human BRCA2 protein promotes RAD51 filament formation on RPA-covered ssDNA
BRCA2 is an important tumor suppressor and functions in homologous recombination, a key genomic integrity pathway. BRCA2 interacts with RAD51, the central protein of recombination, which forms filaments on ssDNA to perform homology search and DNA strand invasion. We report the purification of full-l...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952495/ https://www.ncbi.nlm.nih.gov/pubmed/20729859 http://dx.doi.org/10.1038/nsmb.1904 |