Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis

PURPOSE: To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. METHODS: A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due t...

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Detalles Bibliográficos
Autores principales: Kuennen, Rebecca A, Smith, Reynell Harder, Mauger, Thomas F, Craig, Elson
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952618/
https://www.ncbi.nlm.nih.gov/pubmed/20957062
http://dx.doi.org/10.2147/OPTH.S13831
Descripción
Sumario:PURPOSE: To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. METHODS: A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain. RESULTS: The eye showed Acanthamoeba organisms within the cornea and evidence of acute and chronic inflammation throughout the remainder of the eye. The patient has survived without orbital recurrence for 2 years. CONCLUSIONS: This case demonstrates late inflammation with active Acanthameoba keratitis following systemic pentamidine therapy.

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