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Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis

PURPOSE: To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. METHODS: A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due t...

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Detalles Bibliográficos
Autores principales: Kuennen, Rebecca A, Smith, Reynell Harder, Mauger, Thomas F, Craig, Elson
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952618/
https://www.ncbi.nlm.nih.gov/pubmed/20957062
http://dx.doi.org/10.2147/OPTH.S13831
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author Kuennen, Rebecca A
Smith, Reynell Harder
Mauger, Thomas F
Craig, Elson
author_facet Kuennen, Rebecca A
Smith, Reynell Harder
Mauger, Thomas F
Craig, Elson
author_sort Kuennen, Rebecca A
collection PubMed
description PURPOSE: To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. METHODS: A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain. RESULTS: The eye showed Acanthamoeba organisms within the cornea and evidence of acute and chronic inflammation throughout the remainder of the eye. The patient has survived without orbital recurrence for 2 years. CONCLUSIONS: This case demonstrates late inflammation with active Acanthameoba keratitis following systemic pentamidine therapy.
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spelling pubmed-29526182010-10-18 Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis Kuennen, Rebecca A Smith, Reynell Harder Mauger, Thomas F Craig, Elson Clin Ophthalmol Case Report PURPOSE: To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. METHODS: A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain. RESULTS: The eye showed Acanthamoeba organisms within the cornea and evidence of acute and chronic inflammation throughout the remainder of the eye. The patient has survived without orbital recurrence for 2 years. CONCLUSIONS: This case demonstrates late inflammation with active Acanthameoba keratitis following systemic pentamidine therapy. Dove Medical Press 2010-10-05 2010 /pmc/articles/PMC2952618/ /pubmed/20957062 http://dx.doi.org/10.2147/OPTH.S13831 Text en © 2010 Kuennen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Case Report
Kuennen, Rebecca A
Smith, Reynell Harder
Mauger, Thomas F
Craig, Elson
Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis
title Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis
title_full Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis
title_fullStr Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis
title_full_unstemmed Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis
title_short Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis
title_sort enucleation following treatment with intravenous pentamidine for acanthamoeba sclerokeratitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952618/
https://www.ncbi.nlm.nih.gov/pubmed/20957062
http://dx.doi.org/10.2147/OPTH.S13831
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