Cargando…

Dynamic Determinants of Longevity and Exceptional Health

It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties of age trajectories of the physiological indices...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yashin, Anatoli I., Arbeev, Konstantin G., Akushevich, Igor, Arbeeva, Liubov, Kravchenko, Julia, Il'yasova, Dora, Kulminski, Alexander, Akushevich, Lucy, Culminskaya, Irina, Wu, Deqing, Ukraintseva, Svetlana V.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952789/ https://www.ncbi.nlm.nih.gov/pubmed/20953403 http://dx.doi.org/10.1155/2010/381637

Ejemplares similares

Genetics of aging, health, and survival: dynamic regulation of human longevity related traits
por: Yashin, Anatoliy I., et al.
Publicado: (2015)

How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data
por: Yashin, Anatoliy I., et al.
Publicado: (2013)

Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging
por: Arbeev, Konstantin G., et al.
Publicado: (2012)

How the quality of GWAS of human lifespan and health span can be improved
por: Yashin, Anatoliy I., et al.
Publicado: (2013)

Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures
por: Yashin, Anatoliy I., et al.
Publicado: (2016)

Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants
por: Ukraintseva, Svetlana, et al.
Publicado: (2015)

Biodemographic Analyses of Longitudinal Data on Aging, Health, and Longevity: Recent Advances and Future Perspectives
por: Arbeev, Konstantin G., et al.
Publicado: (2014)

Cancer Risk and Behavioral Factors, Comorbidities, and Functional Status in the US Elderly Population
por: Akushevich, Igor, et al.
Publicado: (2011)

Medical Cost Trajectories and Onsets of Cancer and NonCancer Diseases in US Elderly Population
por: Akushevich, Igor, et al.
Publicado: (2011)

Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies
por: Kulminski, Alexander M., et al.
Publicado: (2015)

The Interplay Between Stress Related Genes and Its Role in Human Longevity: Insights for Translational Studies
por: Yashin, Anatoliy, et al.
Publicado: (2021)

Genes Involved in Physiological Dysregulation and Decline in Resilience: Role in Alzheimer’s Disease
por: Ukraintseva, Svetlana, et al.
Publicado: (2021)

Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival
por: Arbeev, Konstantin G., et al.
Publicado: (2014)

Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk
por: Arbeev, Konstantin G., et al.
Publicado: (2016)

Stress Mediating Genes in Aging, Health, and Longevity Traits: Effects of Multiple Interactions
por: Yashin, Anatoliy, et al.
Publicado: (2020)

PATTERNS OF AGING CHANGES IN BODY WEIGHT AND BMI MAY PREDICT CHANCES OF ALZHEIMER'S DISEASE AND LONGEVITY
por: Ukraintseva, Svetlana, et al.
Publicado: (2022)

Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan
por: Kulminski, Alexander M., et al.
Publicado: (2014)

Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation
por: Ukraintseva, Svetlana, et al.
Publicado: (2021)

Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart‐related traits
por: Kulminski, Alexander M., et al.
Publicado: (2016)

NEW APPROACH TO STUDYING COLLECTIVE EFFECTS OF GENETIC FACTORS ON ALZHEIMER’S DISEASE
por: Yashin, Anatoliy, et al.
Publicado: (2019)

Significant Associations of the Interplay Between Stress Related Genes With Alzheimer’s Disease
por: Yashin, Anatoliy, et al.
Publicado: (2021)

Significant Associations of the Interplay Between Stress Related Genes With Alzheimer’s Disease
por: Yashin, Anatoliy, et al.
Publicado: (2021)

INTERACTIONS BETWEEN GENES FROM AGING-RELATED PATHWAYS: IMPACT ON HUMAN LONGEVITY
por: Ukraintseva, Svetlana, et al.
Publicado: (2019)

How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database
por: Arbeeva, Liubov S., et al.
Publicado: (2018)

Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans
por: Yashin, Anatoliy I., et al.
Publicado: (2021)

Joint influence of small-effect genetic variants on human longevity
por: Yashin, Anatoliy I., et al.
Publicado: (2010)

Applications of Stochastic Process Models to Constructing Predictive Models of Alzheimer’s Disease
por: Arbeev, Konstantin, et al.
Publicado: (2020)

ADULT INFECTIONS ARE ASSOCIATED WITH HIGHER RISK OF ALZHEIMER’S DISEASE BUT LOWER RISK OF CANCER
por: Ukraintseva, Svetlana, et al.
Publicado: (2022)

EFFECTS OF MEDICARE COMORBIDITIES, SELF-REPORTED FACTORS, AND POLYGENIC RISK SCORES IN RISKS OF AD/ADRD
por: Akushevich, Igor, et al.
Publicado: (2019)

The Construction of a Multidomain Risk Model of Alzheimer’s Disease and Related Dementias
por: Akushevich, Igor, et al.
Publicado: (2023)

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Interactions Between Genes From Aging Pathways Significantly Influence Risk of Alzheimer’s Disease
por: Ukraintseva, Svetlana, et al.
Publicado: (2020)

ALZHEIMER’S DISEASE AND COMORBIDITIES: A COMPLEX INTERPLAY IN THE CONTEXT OF AGING
por: Arbeev, Konstantin, et al.
Publicado: (2022)

Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency
por: Kulminski, Alexander M., et al.
Publicado: (2016)

FORECASTING PREVALENCE AND MORTALITY OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS USING PARTITIONING MODELS
por: Akushevich, Igor, et al.
Publicado: (2022)

Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms
por: Kulminski, Alexander M., et al.
Publicado: (2019)

Genetic and regulatory architecture of Alzheimer's disease in the APOE region
por: Kulminski, Alexander M., et al.
Publicado: (2020)

USE OF ANALYTIC METHODS AND MEDICARE DATA IN THE ANALYSES OF DISPARITIES IN AD/ADRD HEALTH OUTCOMES
por: Akushevich, Igor, et al.
Publicado: (2019)

GENETIC ARCHITECTURE OF ALZHEIMER'S DISEASE RISKS
por: Singh, Abanish, et al.
Publicado: (2022)

The Effect of Adherence to Screening Guidelines on the Risk of Alzheimer’s Disease in Elderly Individuals Newly Diagnosed With Type 2 Diabetes Mellitus
por: Yashkin, Arseniy P., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rfujbdqp7tootp7tfkdhaf57rm