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Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals

Transplantation of isolated germ cells from a fertile donor male into the seminiferous tubules of infertile recipients can result in donor-derived sperm production. Therefore, this system represents a major development in the study of spermatogenesis and a unique functional assay to determine the de...

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Detalles Bibliográficos
Autores principales: Honaramooz, Ali, Yang, Yanfei
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952800/
https://www.ncbi.nlm.nih.gov/pubmed/20953408
http://dx.doi.org/10.4061/2011/657860
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author Honaramooz, Ali
Yang, Yanfei
author_facet Honaramooz, Ali
Yang, Yanfei
author_sort Honaramooz, Ali
collection PubMed
description Transplantation of isolated germ cells from a fertile donor male into the seminiferous tubules of infertile recipients can result in donor-derived sperm production. Therefore, this system represents a major development in the study of spermatogenesis and a unique functional assay to determine the developmental potential and relative abundance of spermatogonial stem cells in a given population of testis cells. The application of this method in farm animals has been the subject of an increasing number of studies, mostly because of its potential as an alternative strategy in producing transgenic livestock with higher efficiency and less time and capital requirement than the current methods. This paper highlights the salient recent research on germ cell transplantation in farm animals. The emphasis is placed on the current status of the technique and examination of ways to increase its efficiency through improved preparation of the recipient animals as well as isolation, purification, preservation, and transgenesis of the donor germ cells.
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spelling pubmed-29528002010-10-15 Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals Honaramooz, Ali Yang, Yanfei Vet Med Int Review Article Transplantation of isolated germ cells from a fertile donor male into the seminiferous tubules of infertile recipients can result in donor-derived sperm production. Therefore, this system represents a major development in the study of spermatogenesis and a unique functional assay to determine the developmental potential and relative abundance of spermatogonial stem cells in a given population of testis cells. The application of this method in farm animals has been the subject of an increasing number of studies, mostly because of its potential as an alternative strategy in producing transgenic livestock with higher efficiency and less time and capital requirement than the current methods. This paper highlights the salient recent research on germ cell transplantation in farm animals. The emphasis is placed on the current status of the technique and examination of ways to increase its efficiency through improved preparation of the recipient animals as well as isolation, purification, preservation, and transgenesis of the donor germ cells. SAGE-Hindawi Access to Research 2010-10-04 /pmc/articles/PMC2952800/ /pubmed/20953408 http://dx.doi.org/10.4061/2011/657860 Text en Copyright © 2011 A. Honaramooz and Y. Yang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Honaramooz, Ali
Yang, Yanfei
Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals
title Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals
title_full Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals
title_fullStr Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals
title_full_unstemmed Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals
title_short Recent Advances in Application of Male Germ Cell Transplantation in Farm Animals
title_sort recent advances in application of male germ cell transplantation in farm animals
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952800/
https://www.ncbi.nlm.nih.gov/pubmed/20953408
http://dx.doi.org/10.4061/2011/657860
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