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Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism

Gemfibrozil is a widely prescribed hypolipidemic agent in humans and a peroxisome proliferator and liver carcinogen in rats. Three-month feed studies of gemfibrozil were conducted by the National Toxicology Program (NTP) in male Harlan Sprague-Dawley rats, B6C3F1 mice, and Syrian hamsters, primarily...

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Detalles Bibliográficos
Autores principales:	Cunningham, Michael L., Collins, Bradley J., Hejtmancik, Milton R., Herbert, Ronald A., Travlos, Gregory S., Vallant, Molly K., Stout, Matthew D.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952818/ https://www.ncbi.nlm.nih.gov/pubmed/20953357 http://dx.doi.org/10.1155/2010/681963

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