The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template

Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD). To understand how SOX9 activates transcription, we characterized the DNA binding and cell-free transcription ability of wild-type SOX9 and a dimerization domain SOX9 mutant. Whereas...

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Detalles Bibliográficos
Autores principales: Coustry, Françoise, Oh, Chun-do, Hattori, Takako, Maity, Sankar N., de Crombrugghe, Benoit, Yasuda, Hideyo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952863/
https://www.ncbi.nlm.nih.gov/pubmed/20484372
http://dx.doi.org/10.1093/nar/gkq417

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