Identification of a consensus element recognized and cleaved by IRE1α

IRE1α is an endoplasmic reticulum (ER)-located transmembrane RNase that plays a central role in the ER stress response. Upon ER stress, IRE1α is activated and cleaves specific exon–intron sites in the mRNA encoding the transcription factor X-box-binding protein 1 (XBP1). In addition, previous studie...

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Detalles Bibliográficos
Autores principales: Oikawa, Daisuke, Tokuda, Mio, Hosoda, Akira, Iwawaki, Takao
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952871/
https://www.ncbi.nlm.nih.gov/pubmed/20507909
http://dx.doi.org/10.1093/nar/gkq452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952871/
https://www.ncbi.nlm.nih.gov/pubmed/20507909
http://dx.doi.org/10.1093/nar/gkq452

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