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A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA

Dnmt3a and Dnmt3b are paralogous enzymes responsible for de novo DNA methylation but with distinguished biological functions. In mice, disruption of Dnmt3b but not Dnmt3a causes global DNA hypomethylation, especially in repetitive sequences, which comprise the large majority of methylated DNA in the...

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Detalles Bibliográficos
Autores principales:	Shen, Li, Gao, Ge, Zhang, Ying, Zhang, He, Ye, Zhiqiang, Huang, Shichao, Huang, Jinyan, Kang, Jiuhong
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952872/ https://www.ncbi.nlm.nih.gov/pubmed/20507910 http://dx.doi.org/10.1093/nar/gkq456

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