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Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease
The etiology of the sporadic form of Alzheimer's disease (AD) remains largely unknown. Recent evidence has suggested that gene-environment interactions (GxE) may play a crucial role in its development and progression. Whereas various susceptibility loci have been identified, like the apolipopro...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952897/ https://www.ncbi.nlm.nih.gov/pubmed/20953364 http://dx.doi.org/10.4061/2010/859101 |
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author | Chouliaras, L. Sierksma, A. S. R. Kenis, G. Prickaerts, J. Lemmens, M. A. M. Brasnjevic, I. van Donkelaar, E. L. Martinez-Martinez, P. Losen, M. De Baets, M. H. Kholod, N. van Leeuwen, F. Hof, P. R. van Os, J. Steinbusch, H. W. M. van den Hove, D. L. A. Rutten, B. P. F. |
author_facet | Chouliaras, L. Sierksma, A. S. R. Kenis, G. Prickaerts, J. Lemmens, M. A. M. Brasnjevic, I. van Donkelaar, E. L. Martinez-Martinez, P. Losen, M. De Baets, M. H. Kholod, N. van Leeuwen, F. Hof, P. R. van Os, J. Steinbusch, H. W. M. van den Hove, D. L. A. Rutten, B. P. F. |
author_sort | Chouliaras, L. |
collection | PubMed |
description | The etiology of the sporadic form of Alzheimer's disease (AD) remains largely unknown. Recent evidence has suggested that gene-environment interactions (GxE) may play a crucial role in its development and progression. Whereas various susceptibility loci have been identified, like the apolipoprotein E4 allele, these cannot fully explain the increasing prevalence of AD observed with aging. In addition to such genetic risk factors, various environmental factors have been proposed to alter the risk of developing AD as well as to affect the rate of cognitive decline in AD patients. Nevertheless, aside from the independent effects of genetic and environmental risk factors, their synergistic participation in increasing the risk of developing AD has been sparsely investigated, even though evidence points towards such a direction. Advances in the genetic manipulation of mice, modeling various aspects of the AD pathology, have provided an excellent tool to dissect the effects of genes, environment, and their interactions. In this paper we present several environmental factors implicated in the etiology of AD that have been tested in transgenic animal models of the disease. The focus lies on the concept of GxE and its importance in a multifactorial disease like AD. Additionally, possible mediating mechanisms and future challenges are discussed. |
format | Text |
id | pubmed-2952897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-29528972010-10-15 Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease Chouliaras, L. Sierksma, A. S. R. Kenis, G. Prickaerts, J. Lemmens, M. A. M. Brasnjevic, I. van Donkelaar, E. L. Martinez-Martinez, P. Losen, M. De Baets, M. H. Kholod, N. van Leeuwen, F. Hof, P. R. van Os, J. Steinbusch, H. W. M. van den Hove, D. L. A. Rutten, B. P. F. Int J Alzheimers Dis Review Article The etiology of the sporadic form of Alzheimer's disease (AD) remains largely unknown. Recent evidence has suggested that gene-environment interactions (GxE) may play a crucial role in its development and progression. Whereas various susceptibility loci have been identified, like the apolipoprotein E4 allele, these cannot fully explain the increasing prevalence of AD observed with aging. In addition to such genetic risk factors, various environmental factors have been proposed to alter the risk of developing AD as well as to affect the rate of cognitive decline in AD patients. Nevertheless, aside from the independent effects of genetic and environmental risk factors, their synergistic participation in increasing the risk of developing AD has been sparsely investigated, even though evidence points towards such a direction. Advances in the genetic manipulation of mice, modeling various aspects of the AD pathology, have provided an excellent tool to dissect the effects of genes, environment, and their interactions. In this paper we present several environmental factors implicated in the etiology of AD that have been tested in transgenic animal models of the disease. The focus lies on the concept of GxE and its importance in a multifactorial disease like AD. Additionally, possible mediating mechanisms and future challenges are discussed. SAGE-Hindawi Access to Research 2010-10-05 /pmc/articles/PMC2952897/ /pubmed/20953364 http://dx.doi.org/10.4061/2010/859101 Text en Copyright © 2010 L. Chouliaras et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chouliaras, L. Sierksma, A. S. R. Kenis, G. Prickaerts, J. Lemmens, M. A. M. Brasnjevic, I. van Donkelaar, E. L. Martinez-Martinez, P. Losen, M. De Baets, M. H. Kholod, N. van Leeuwen, F. Hof, P. R. van Os, J. Steinbusch, H. W. M. van den Hove, D. L. A. Rutten, B. P. F. Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease |
title | Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease |
title_full | Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease |
title_fullStr | Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease |
title_full_unstemmed | Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease |
title_short | Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease |
title_sort | gene-environment interaction research and transgenic mouse models of alzheimer's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952897/ https://www.ncbi.nlm.nih.gov/pubmed/20953364 http://dx.doi.org/10.4061/2010/859101 |
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