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Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity

Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets...

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Detalles Bibliográficos
Autores principales: Sears, Barry, Ricordi, Camillo
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952901/
https://www.ncbi.nlm.nih.gov/pubmed/20953366
http://dx.doi.org/10.1155/2011/431985
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author Sears, Barry
Ricordi, Camillo
author_facet Sears, Barry
Ricordi, Camillo
author_sort Sears, Barry
collection PubMed
description Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities.
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spelling pubmed-29529012010-10-15 Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity Sears, Barry Ricordi, Camillo J Obes Review Article Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities. Hindawi Publishing Corporation 2011 2010-09-30 /pmc/articles/PMC2952901/ /pubmed/20953366 http://dx.doi.org/10.1155/2011/431985 Text en Copyright © 2011 B. Sears and C. Ricordi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sears, Barry
Ricordi, Camillo
Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
title Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
title_full Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
title_fullStr Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
title_full_unstemmed Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
title_short Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
title_sort anti-inflammatory nutrition as a pharmacological approach to treat obesity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952901/
https://www.ncbi.nlm.nih.gov/pubmed/20953366
http://dx.doi.org/10.1155/2011/431985
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