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Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity
Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952901/ https://www.ncbi.nlm.nih.gov/pubmed/20953366 http://dx.doi.org/10.1155/2011/431985 |
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author | Sears, Barry Ricordi, Camillo |
author_facet | Sears, Barry Ricordi, Camillo |
author_sort | Sears, Barry |
collection | PubMed |
description | Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities. |
format | Text |
id | pubmed-2952901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29529012010-10-15 Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity Sears, Barry Ricordi, Camillo J Obes Review Article Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities. Hindawi Publishing Corporation 2011 2010-09-30 /pmc/articles/PMC2952901/ /pubmed/20953366 http://dx.doi.org/10.1155/2011/431985 Text en Copyright © 2011 B. Sears and C. Ricordi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sears, Barry Ricordi, Camillo Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
title | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
title_full | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
title_fullStr | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
title_full_unstemmed | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
title_short | Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity |
title_sort | anti-inflammatory nutrition as a pharmacological approach to treat obesity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952901/ https://www.ncbi.nlm.nih.gov/pubmed/20953366 http://dx.doi.org/10.1155/2011/431985 |
work_keys_str_mv | AT searsbarry antiinflammatorynutritionasapharmacologicalapproachtotreatobesity AT ricordicamillo antiinflammatorynutritionasapharmacologicalapproachtotreatobesity |