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Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex

The Golgi complex performs a central function in the secretory pathway in the sorting and sequential processing of a large number of proteins destined for other endomembrane organelles, the plasma membrane, or secretion from the cell, in addition to lipid metabolism and signaling. The Golgi apparatu...

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Detalles Bibliográficos
Autores principales: Wilson, Cathal, Ragnini-Wilson, Antonella
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952910/
https://www.ncbi.nlm.nih.gov/pubmed/20976261
http://dx.doi.org/10.1155/2010/758230
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author Wilson, Cathal
Ragnini-Wilson, Antonella
author_facet Wilson, Cathal
Ragnini-Wilson, Antonella
author_sort Wilson, Cathal
collection PubMed
description The Golgi complex performs a central function in the secretory pathway in the sorting and sequential processing of a large number of proteins destined for other endomembrane organelles, the plasma membrane, or secretion from the cell, in addition to lipid metabolism and signaling. The Golgi apparatus can be regarded as a self-organizing system that maintains a relatively stable morphofunctional organization in the face of an enormous flux of lipids and proteins. A large number of the molecular players that operate in these processes have been identified, their functions and interactions defined, but there is still debate about many aspects that regulate protein trafficking and, in particular, the maintenance of these highly dynamic structures and processes. Here, we consider how an evolutionarily conserved underlying mechanism based on retrograde trafficking that uses lipids, COPI, SNAREs, and tethers could maintain such a homeodynamic system.
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spelling pubmed-29529102010-10-25 Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex Wilson, Cathal Ragnini-Wilson, Antonella Int J Cell Biol Review Article The Golgi complex performs a central function in the secretory pathway in the sorting and sequential processing of a large number of proteins destined for other endomembrane organelles, the plasma membrane, or secretion from the cell, in addition to lipid metabolism and signaling. The Golgi apparatus can be regarded as a self-organizing system that maintains a relatively stable morphofunctional organization in the face of an enormous flux of lipids and proteins. A large number of the molecular players that operate in these processes have been identified, their functions and interactions defined, but there is still debate about many aspects that regulate protein trafficking and, in particular, the maintenance of these highly dynamic structures and processes. Here, we consider how an evolutionarily conserved underlying mechanism based on retrograde trafficking that uses lipids, COPI, SNAREs, and tethers could maintain such a homeodynamic system. Hindawi Publishing Corporation 2010 2010-10-03 /pmc/articles/PMC2952910/ /pubmed/20976261 http://dx.doi.org/10.1155/2010/758230 Text en Copyright © 2010 C. Wilson and A. Ragnini-Wilson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wilson, Cathal
Ragnini-Wilson, Antonella
Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex
title Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex
title_full Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex
title_fullStr Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex
title_full_unstemmed Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex
title_short Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex
title_sort conserved molecular mechanisms underlying homeostasis of the golgi complex
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952910/
https://www.ncbi.nlm.nih.gov/pubmed/20976261
http://dx.doi.org/10.1155/2010/758230
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