LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

LIM kinases 1 and 2 (LIMK1/2) are centrally positioned regulators of actin cytoskeleton dynamics. Using siRNA-mediated knockdown or a novel small molecule inhibitor, we show LIMK is required for path generation by leading tumor cells and nontumor stromal cells during collective tumor cell invasion....

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Detalles Bibliográficos
Autores principales: Scott, Rebecca W., Hooper, Steven, Crighton, Diane, Li, Ang, König, Ireen, Munro, June, Trivier, Elisabeth, Wickman, Grant, Morin, Pierre, Croft, Daniel R., Dawson, John, Machesky, Laura, Anderson, Kurt I., Sahai, Erik A., Olson, Michael F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953444/
https://www.ncbi.nlm.nih.gov/pubmed/20876278
http://dx.doi.org/10.1083/jcb.201002041

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