The two faces of serotonin in bone biology

The serotonin molecule has some remarkable properties. It is synthesized by two different genes at two different sites, and, surprisingly, plays antagonistic functions on bone mass accrual at these two sites. When produced peripherally, serotonin acts as a hormone to inhibit bone formation. In contr...

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Detalles Bibliográficos
Autores principales: Ducy, Patricia, Karsenty, Gerard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953449/
https://www.ncbi.nlm.nih.gov/pubmed/20921133
http://dx.doi.org/10.1083/jcb.201006123
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author Ducy, Patricia
Karsenty, Gerard
author_facet Ducy, Patricia
Karsenty, Gerard
author_sort Ducy, Patricia
collection PubMed
description The serotonin molecule has some remarkable properties. It is synthesized by two different genes at two different sites, and, surprisingly, plays antagonistic functions on bone mass accrual at these two sites. When produced peripherally, serotonin acts as a hormone to inhibit bone formation. In contrast, when produced in the brain, serotonin acts as a neurotransmitter to exert a positive and dominant effect on bone mass accrual by enhancing bone formation and limiting bone resorption. The effect of serotonin on bone biology could be harnessed pharmacologically to treat diseases such as osteoporosis.
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spelling pubmed-29534492011-04-04 The two faces of serotonin in bone biology Ducy, Patricia Karsenty, Gerard J Cell Biol Reviews The serotonin molecule has some remarkable properties. It is synthesized by two different genes at two different sites, and, surprisingly, plays antagonistic functions on bone mass accrual at these two sites. When produced peripherally, serotonin acts as a hormone to inhibit bone formation. In contrast, when produced in the brain, serotonin acts as a neurotransmitter to exert a positive and dominant effect on bone mass accrual by enhancing bone formation and limiting bone resorption. The effect of serotonin on bone biology could be harnessed pharmacologically to treat diseases such as osteoporosis. The Rockefeller University Press 2010-10-04 /pmc/articles/PMC2953449/ /pubmed/20921133 http://dx.doi.org/10.1083/jcb.201006123 Text en © 2010 Ducy and Karsenty This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Ducy, Patricia
Karsenty, Gerard
The two faces of serotonin in bone biology
title The two faces of serotonin in bone biology
title_full The two faces of serotonin in bone biology
title_fullStr The two faces of serotonin in bone biology
title_full_unstemmed The two faces of serotonin in bone biology
title_short The two faces of serotonin in bone biology
title_sort two faces of serotonin in bone biology
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953449/
https://www.ncbi.nlm.nih.gov/pubmed/20921133
http://dx.doi.org/10.1083/jcb.201006123
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