Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level

We recently found that lithocholic acid (LCA), a bile acid, extends yeast longevity. Unlike mammals, yeast do not synthesize bile acids. We therefore propose that bile acids released into the environment by mammals may act as interspecies chemical signals providing longevity benefits to yeast and, p...

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Detalles Bibliográficos
Autores principales: Goldberg, Alexander A., Kyryakov, Pavlo, Bourque, Simon D., Titorenko, Vladimir I.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954037/
https://www.ncbi.nlm.nih.gov/pubmed/20693605
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author Goldberg, Alexander A.
Kyryakov, Pavlo
Bourque, Simon D.
Titorenko, Vladimir I.
author_facet Goldberg, Alexander A.
Kyryakov, Pavlo
Bourque, Simon D.
Titorenko, Vladimir I.
author_sort Goldberg, Alexander A.
collection PubMed
description We recently found that lithocholic acid (LCA), a bile acid, extends yeast longevity. Unlike mammals, yeast do not synthesize bile acids. We therefore propose that bile acids released into the environment by mammals may act as interspecies chemical signals providing longevity benefits to yeast and, perhaps, other species within an ecosystem.
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spelling pubmed-29540372010-10-14 Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level Goldberg, Alexander A. Kyryakov, Pavlo Bourque, Simon D. Titorenko, Vladimir I. Aging (Albany NY) Hypothesis We recently found that lithocholic acid (LCA), a bile acid, extends yeast longevity. Unlike mammals, yeast do not synthesize bile acids. We therefore propose that bile acids released into the environment by mammals may act as interspecies chemical signals providing longevity benefits to yeast and, perhaps, other species within an ecosystem. Impact Journals LLC 2010-08-07 /pmc/articles/PMC2954037/ /pubmed/20693605 Text en Copyright: ©2010 Goldberg et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Goldberg, Alexander A.
Kyryakov, Pavlo
Bourque, Simon D.
Titorenko, Vladimir I.
Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
title Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
title_full Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
title_fullStr Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
title_full_unstemmed Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
title_short Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
title_sort xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954037/
https://www.ncbi.nlm.nih.gov/pubmed/20693605
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AT bourquesimond xenohormetichormeticandcytostaticselectiveforcesdrivinglongevityattheecosystemiclevel
AT titorenkovladimiri xenohormetichormeticandcytostaticselectiveforcesdrivinglongevityattheecosystemiclevel

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