p53, ROS and senescence in the control of aging

Abstract: In addition to its function as a tumour suppressor, p53 is also involved in an increasing number of pathology associated with aging. Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senes...

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Detalles Bibliográficos
Autores principales: Vigneron, Arnaud, Vousden, Karen H
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954038/
https://www.ncbi.nlm.nih.gov/pubmed/20729567
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author Vigneron, Arnaud
Vousden, Karen H
author_facet Vigneron, Arnaud
Vousden, Karen H
author_sort Vigneron, Arnaud
collection PubMed
description Abstract: In addition to its function as a tumour suppressor, p53 is also involved in an increasing number of pathology associated with aging. Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senescence. The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.
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spelling pubmed-29540382010-10-14 p53, ROS and senescence in the control of aging Vigneron, Arnaud Vousden, Karen H Aging (Albany NY) Review Abstract: In addition to its function as a tumour suppressor, p53 is also involved in an increasing number of pathology associated with aging. Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senescence. The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging. Impact Journals LLC 2010-08-16 /pmc/articles/PMC2954038/ /pubmed/20729567 Text en Copyright: ©2010 Vigneron et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Vigneron, Arnaud
Vousden, Karen H
p53, ROS and senescence in the control of aging
title p53, ROS and senescence in the control of aging
title_full p53, ROS and senescence in the control of aging
title_fullStr p53, ROS and senescence in the control of aging
title_full_unstemmed p53, ROS and senescence in the control of aging
title_short p53, ROS and senescence in the control of aging
title_sort p53, ros and senescence in the control of aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954038/
https://www.ncbi.nlm.nih.gov/pubmed/20729567
work_keys_str_mv AT vigneronarnaud p53rosandsenescenceinthecontrolofaging
AT vousdenkarenh p53rosandsenescenceinthecontrolofaging

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