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Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr-1, Not Pfcrt in Madagascar
Molecular studies have demonstrated that mutations in the Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) play a major role in chloroquine resistance, while mutations in P. falciparum multidrug resistance gene (Pfmdr-1) act as modulator. In Madagascar, the high rate of chloroqu...
Autores principales: | Andriantsoanirina, Valérie, Ratsimbasoa, Arsène, Bouchier, Christiane, Tichit, Magali, Jahevitra, Martial, Rabearimanana, Stéphane, Raherinjafy, Rogelin, Mercereau-Puijalon, Odile, Durand, Rémy, Ménard, Didier |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954150/ https://www.ncbi.nlm.nih.gov/pubmed/20967251 http://dx.doi.org/10.1371/journal.pone.0013281 |
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