Specific Variants in the MLH1 Gene Region May Drive DNA Methylation, Loss of Protein Expression, and MSI-H Colorectal Cancer

BACKGROUND: We previously identified an association between a mismatch repair gene, MLH1, promoter SNP (rs1800734) and microsatellite unstable (MSI-H) colorectal cancers (CRCs) in two samples. The current study expanded on this finding as we explored the genetic basis of DNA methylation in this regi...

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Detalles Bibliográficos
Autores principales: Mrkonjic, Miralem, Roslin, Nicole M., Greenwood, Celia M., Raptis, Stavroula, Pollett, Aaron, Laird, Peter W., Pethe, Vaijayanti V., Chiang, Theodore, Daftary, Darshana, Dicks, Elizabeth, Thibodeau, Stephen N., Gallinger, Steven, Parfrey, Patrick S., Younghusband, H. Banfield, Potter, John D., Hudson, Thomas J., McLaughlin, John R., Green, Roger C., Zanke, Brent W., Newcomb, Polly A., Paterson, Andrew D., Bapat, Bharati
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954166/
https://www.ncbi.nlm.nih.gov/pubmed/20967208
http://dx.doi.org/10.1371/journal.pone.0013314

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