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Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy
Mislocalization, aberrant processing and aggregation of TAR DNA-binding protein 43 (TDP-43) is found in the neurons affected by two related diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobe dementia (FTLD). These TDP-43 abnormalities are seen when TDP-43 is mutated, such as in fa...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954192/ https://www.ncbi.nlm.nih.gov/pubmed/20967127 http://dx.doi.org/10.1371/journal.pone.0013368 |