Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism

The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-­terminal domain, combined with remote sequence similarity to two other prot...

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Detalles Bibliográficos
Autores principales: Chiu, Hsiu-Ju, Bakolitsa, Constantina, Skerra, Arne, Lomize, Andrei, Carlton, Dennis, Miller, Mitchell D., Krishna, S. Sri, Abdubek, Polat, Astakhova, Tamara, Axelrod, Herbert L., Clayton, Thomas, Deller, Marc C., Duan, Lian, Feuerhelm, Julie, Grant, Joanna C., Grzechnik, Slawomir K., Han, Gye Won, Jaroszewski, Lukasz, Jin, Kevin K., Klock, Heath E., Knuth, Mark W., Kozbial, Piotr, Kumar, Abhinav, Marciano, David, McMullan, Daniel, Morse, Andrew T., Nigoghossian, Edward, Okach, Linda, Paulsen, Jessica, Reyes, Ron, Rife, Christopher L., van den Bedem, Henry, Weekes, Dana, Xu, Qingping, Hodgson, Keith O., Wooley, John, Elsliger, Marc-André, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Wilson, Ian A.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Domains of Unknown Function
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954199/
https://www.ncbi.nlm.nih.gov/pubmed/20944205
http://dx.doi.org/10.1107/S1744309109037749
Descripción
Sumario:The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-­terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively.

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