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Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism
The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other prot...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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International Union of Crystallography
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954199/ https://www.ncbi.nlm.nih.gov/pubmed/20944205 http://dx.doi.org/10.1107/S1744309109037749 |
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| author | Chiu, Hsiu-Ju Bakolitsa, Constantina Skerra, Arne Lomize, Andrei Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Paulsen, Jessica Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_facet | Chiu, Hsiu-Ju Bakolitsa, Constantina Skerra, Arne Lomize, Andrei Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Paulsen, Jessica Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_sort | Chiu, Hsiu-Ju |
| collection | PubMed |
| description | The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively. |
| format | Text |
| id | pubmed-2954199 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29541992010-10-27 Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism Chiu, Hsiu-Ju Bakolitsa, Constantina Skerra, Arne Lomize, Andrei Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Paulsen, Jessica Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun Domains of Unknown Function The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively. International Union of Crystallography 2009-12-08 /pmc/articles/PMC2954199/ /pubmed/20944205 http://dx.doi.org/10.1107/S1744309109037749 Text en © Chiu et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Domains of Unknown Function Chiu, Hsiu-Ju Bakolitsa, Constantina Skerra, Arne Lomize, Andrei Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Paulsen, Jessica Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism |
| title | Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism |
| title_full | Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism |
| title_fullStr | Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism |
| title_full_unstemmed | Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism |
| title_short | Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism |
| title_sort | structure of the first representative of pfam family pf09410 (duf2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism |
| topic | Domains of Unknown Function |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954199/ https://www.ncbi.nlm.nih.gov/pubmed/20944205 http://dx.doi.org/10.1107/S1744309109037749 |
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