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The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role
SSO2064 is the first structural representative of PF01796 (DUF35), a large prokaryotic family with a wide phylogenetic distribution. The structure reveals a novel two-domain architecture comprising an N-terminal, rubredoxin-like, zinc ribbon and a C-terminal, oligonucleotide/oligosaccharide-binding...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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International Union of Crystallography
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954200/ https://www.ncbi.nlm.nih.gov/pubmed/20944206 http://dx.doi.org/10.1107/S1744309110002514 |
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| author | Krishna, S. Sri Aravind, L. Bakolitsa, Constantina Caruthers, Jonathan Carlton, Dennis Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_facet | Krishna, S. Sri Aravind, L. Bakolitsa, Constantina Caruthers, Jonathan Carlton, Dennis Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_sort | Krishna, S. Sri |
| collection | PubMed |
| description | SSO2064 is the first structural representative of PF01796 (DUF35), a large prokaryotic family with a wide phylogenetic distribution. The structure reveals a novel two-domain architecture comprising an N-terminal, rubredoxin-like, zinc ribbon and a C-terminal, oligonucleotide/oligosaccharide-binding (OB) fold domain. Additional N-terminal helical segments may be involved in protein–protein interactions. Domain architectures, genomic context analysis and functional evidence from certain bacterial representatives of this family suggest that these proteins form a novel fatty-acid-binding component that is involved in the biosynthesis of lipids and polyketide antibiotics and that they possibly function as acyl-CoA-binding proteins. This structure has led to a re-evaluation of the DUF35 family, which has now been split into two entries in the latest Pfam release (v.24.0). |
| format | Text |
| id | pubmed-2954200 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29542002010-10-27 The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role Krishna, S. Sri Aravind, L. Bakolitsa, Constantina Caruthers, Jonathan Carlton, Dennis Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun Domains of Unknown Function SSO2064 is the first structural representative of PF01796 (DUF35), a large prokaryotic family with a wide phylogenetic distribution. The structure reveals a novel two-domain architecture comprising an N-terminal, rubredoxin-like, zinc ribbon and a C-terminal, oligonucleotide/oligosaccharide-binding (OB) fold domain. Additional N-terminal helical segments may be involved in protein–protein interactions. Domain architectures, genomic context analysis and functional evidence from certain bacterial representatives of this family suggest that these proteins form a novel fatty-acid-binding component that is involved in the biosynthesis of lipids and polyketide antibiotics and that they possibly function as acyl-CoA-binding proteins. This structure has led to a re-evaluation of the DUF35 family, which has now been split into two entries in the latest Pfam release (v.24.0). International Union of Crystallography 2010-03-05 /pmc/articles/PMC2954200/ /pubmed/20944206 http://dx.doi.org/10.1107/S1744309110002514 Text en © Krishna et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Domains of Unknown Function Krishna, S. Sri Aravind, L. Bakolitsa, Constantina Caruthers, Jonathan Carlton, Dennis Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Feuerhelm, Julie Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kumar, Abhinav Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role |
| title | The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role |
| title_full | The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role |
| title_fullStr | The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role |
| title_full_unstemmed | The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role |
| title_short | The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role |
| title_sort | structure of sso2064, the first representative of pfam family pf01796, reveals a novel two-domain zinc-ribbon ob-fold architecture with a potential acyl-coa-binding role |
| topic | Domains of Unknown Function |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954200/ https://www.ncbi.nlm.nih.gov/pubmed/20944206 http://dx.doi.org/10.1107/S1744309110002514 |
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