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The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation
Proteins with the DUF2063 domain constitute a new Pfam family, PF09836. The crystal structure of a member of this family, NGO1945 from Neisseria gonorrhoeae, has been determined and reveals that the N-terminal DUF2063 domain is likely to be a DNA-binding domain. In conjunction with the rest of the p...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954202/ https://www.ncbi.nlm.nih.gov/pubmed/20944208 http://dx.doi.org/10.1107/S1744309109022672 |
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| author | Das, Debanu Grishin, Nick V. Kumar, Abhinav Carlton, Dennis Bakolitsa, Constantina Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_facet | Das, Debanu Grishin, Nick V. Kumar, Abhinav Carlton, Dennis Bakolitsa, Constantina Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_sort | Das, Debanu |
| collection | PubMed |
| description | Proteins with the DUF2063 domain constitute a new Pfam family, PF09836. The crystal structure of a member of this family, NGO1945 from Neisseria gonorrhoeae, has been determined and reveals that the N-terminal DUF2063 domain is likely to be a DNA-binding domain. In conjunction with the rest of the protein, NGO1945 is likely to be involved in transcriptional regulation, which is consistent with genomic neighborhood analysis. Of the 216 currently known proteins that contain a DUF2063 domain, the most significant sequence homologs of NGO1945 (∼40–99% sequence identity) are from various Neisseria and Haemophilus species. As these are important human pathogens, NGO1945 represents an interesting candidate for further exploration via biochemical studies and possible therapeutic intervention. |
| format | Text |
| id | pubmed-2954202 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29542022010-10-27 The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation Das, Debanu Grishin, Nick V. Kumar, Abhinav Carlton, Dennis Bakolitsa, Constantina Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun Domains of Unknown Function Proteins with the DUF2063 domain constitute a new Pfam family, PF09836. The crystal structure of a member of this family, NGO1945 from Neisseria gonorrhoeae, has been determined and reveals that the N-terminal DUF2063 domain is likely to be a DNA-binding domain. In conjunction with the rest of the protein, NGO1945 is likely to be involved in transcriptional regulation, which is consistent with genomic neighborhood analysis. Of the 216 currently known proteins that contain a DUF2063 domain, the most significant sequence homologs of NGO1945 (∼40–99% sequence identity) are from various Neisseria and Haemophilus species. As these are important human pathogens, NGO1945 represents an interesting candidate for further exploration via biochemical studies and possible therapeutic intervention. International Union of Crystallography 2009-10-27 /pmc/articles/PMC2954202/ /pubmed/20944208 http://dx.doi.org/10.1107/S1744309109022672 Text en © Das et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Domains of Unknown Function Das, Debanu Grishin, Nick V. Kumar, Abhinav Carlton, Dennis Bakolitsa, Constantina Miller, Mitchell D. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation |
| title | The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation |
| title_full | The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation |
| title_fullStr | The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation |
| title_full_unstemmed | The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation |
| title_short | The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation |
| title_sort | structure of the first representative of pfam family pf09836 reveals a two-domain organization and suggests involvement in transcriptional regulation |
| topic | Domains of Unknown Function |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954202/ https://www.ncbi.nlm.nih.gov/pubmed/20944208 http://dx.doi.org/10.1107/S1744309109022672 |
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