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The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator
The crystal structure of Jann_2411 from Jannaschia sp. strain CCS1, a member of the Pfam PF07336 family classified as a domain of unknown function (DUF1470), was solved to a resolution of 1.45 Å by multiple-wavelength anomalous dispersion (MAD). This protein is the first structural representative of...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954205/ https://www.ncbi.nlm.nih.gov/pubmed/20944211 http://dx.doi.org/10.1107/S1744309109025196 |
| _version_ | 1782187903968870400 |
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| author | Bakolitsa, Constantina Bateman, Alex Jin, Kevin K. McMullan, Daniel Krishna, S. Sri Miller, Mitchell D. Abdubek, Polat Acosta, Claire Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Carlton, Dennis Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Elias, Ylva Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David Morse, Andrew T. Murphy, Kevin D. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry Trame, Christine B. Trout, Christina V. van den Bedem, Henry Weekes, Dana White, Aprilfawn Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott Wilson, Ian A. |
| author_facet | Bakolitsa, Constantina Bateman, Alex Jin, Kevin K. McMullan, Daniel Krishna, S. Sri Miller, Mitchell D. Abdubek, Polat Acosta, Claire Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Carlton, Dennis Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Elias, Ylva Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David Morse, Andrew T. Murphy, Kevin D. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry Trame, Christine B. Trout, Christina V. van den Bedem, Henry Weekes, Dana White, Aprilfawn Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott Wilson, Ian A. |
| author_sort | Bakolitsa, Constantina |
| collection | PubMed |
| description | The crystal structure of Jann_2411 from Jannaschia sp. strain CCS1, a member of the Pfam PF07336 family classified as a domain of unknown function (DUF1470), was solved to a resolution of 1.45 Å by multiple-wavelength anomalous dispersion (MAD). This protein is the first structural representative of the DUF1470 Pfam family. Structural analysis revealed a two-domain organization, with the N-terminal domain presenting a new fold called the ABATE domain that may bind an as yet unknown ligand. The C-terminal domain forms a treble-clef zinc finger that is likely to be involved in DNA binding. Analysis of the Jann_2411 protein and the broader ABATE-domain family suggests a role as stress-induced transcriptional regulators. |
| format | Text |
| id | pubmed-2954205 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29542052010-10-27 The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator Bakolitsa, Constantina Bateman, Alex Jin, Kevin K. McMullan, Daniel Krishna, S. Sri Miller, Mitchell D. Abdubek, Polat Acosta, Claire Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Carlton, Dennis Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Elias, Ylva Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David Morse, Andrew T. Murphy, Kevin D. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry Trame, Christine B. Trout, Christina V. van den Bedem, Henry Weekes, Dana White, Aprilfawn Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun New Folds The crystal structure of Jann_2411 from Jannaschia sp. strain CCS1, a member of the Pfam PF07336 family classified as a domain of unknown function (DUF1470), was solved to a resolution of 1.45 Å by multiple-wavelength anomalous dispersion (MAD). This protein is the first structural representative of the DUF1470 Pfam family. Structural analysis revealed a two-domain organization, with the N-terminal domain presenting a new fold called the ABATE domain that may bind an as yet unknown ligand. The C-terminal domain forms a treble-clef zinc finger that is likely to be involved in DNA binding. Analysis of the Jann_2411 protein and the broader ABATE-domain family suggests a role as stress-induced transcriptional regulators. International Union of Crystallography 2009-10-27 /pmc/articles/PMC2954205/ /pubmed/20944211 http://dx.doi.org/10.1107/S1744309109025196 Text en © Bakolitsa et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | New Folds Bakolitsa, Constantina Bateman, Alex Jin, Kevin K. McMullan, Daniel Krishna, S. Sri Miller, Mitchell D. Abdubek, Polat Acosta, Claire Astakhova, Tamara Axelrod, Herbert L. Burra, Prasad Carlton, Dennis Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Elias, Ylva Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Grzechnik, Slawomir K. Han, Gye Won Jaroszewski, Lukasz Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Kumar, Abhinav Marciano, David Morse, Andrew T. Murphy, Kevin D. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry Trame, Christine B. Trout, Christina V. van den Bedem, Henry Weekes, Dana White, Aprilfawn Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott Wilson, Ian A. The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator |
| title | The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator |
| title_full | The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator |
| title_fullStr | The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator |
| title_full_unstemmed | The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator |
| title_short | The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator |
| title_sort | structure of jann_2411 (duf1470) from jannaschia sp. at 1.45 å resolution reveals a new fold (the abate domain) and suggests its possible role as a transcription regulator |
| topic | New Folds |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954205/ https://www.ncbi.nlm.nih.gov/pubmed/20944211 http://dx.doi.org/10.1107/S1744309109025196 |
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structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT tramechristineb structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT troutchristinav structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT vandenbedemhenry structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT weekesdana structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT whiteaprilfawn structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT xuqingping structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT hodgsonkeitho structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT wooleyjohn structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT elsligermarcandre structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT deaconashleym structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT godzikadam structureofjann2411duf1470fromjannaschiaspat145aresolutionrevealsanewfoldtheabatedomainandsuggestsitspossibleroleasatranscriptionregulator AT lesleyscott 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