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Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism
The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokary...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954206/ https://www.ncbi.nlm.nih.gov/pubmed/20944212 http://dx.doi.org/10.1107/S1744309109023689 |
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| author | Bakolitsa, Constantina Kumar, Abhinav Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Elsliger, Marc-André Feuerhelm, Julie Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Tien, Henry J. Trout, Christina V. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_facet | Bakolitsa, Constantina Kumar, Abhinav Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Elsliger, Marc-André Feuerhelm, Julie Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Tien, Henry J. Trout, Christina V. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_sort | Bakolitsa, Constantina |
| collection | PubMed |
| description | The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968. |
| format | Text |
| id | pubmed-2954206 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29542062010-10-27 Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism Bakolitsa, Constantina Kumar, Abhinav Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Elsliger, Marc-André Feuerhelm, Julie Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Tien, Henry J. Trout, Christina V. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun New Folds The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968. International Union of Crystallography 2009-10-27 /pmc/articles/PMC2954206/ /pubmed/20944212 http://dx.doi.org/10.1107/S1744309109023689 Text en © Bakolitsa et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | New Folds Bakolitsa, Constantina Kumar, Abhinav Carlton, Dennis Miller, Mitchell D. Krishna, S. Sri Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chiu, Hsiu-Ju Clayton, Thomas Deller, Marc C. Duan, Lian Elsliger, Marc-André Feuerhelm, Julie Grzechnik, Slawomir K. Grant, Joanna C. Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Oommachen, Silvya Paulsen, Jessica Reyes, Ron Rife, Christopher L. Tien, Henry J. Trout, Christina V. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism |
| title | Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism |
| title_full | Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism |
| title_fullStr | Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism |
| title_full_unstemmed | Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism |
| title_short | Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism |
| title_sort | structure of lp2179, the first representative of pfam family pf08866, suggests a new fold with a role in amino-acid metabolism |
| topic | New Folds |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954206/ https://www.ncbi.nlm.nih.gov/pubmed/20944212 http://dx.doi.org/10.1107/S1744309109023689 |
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