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Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction
The crystal structures of SPO0140 and Sbal_2486 were determined using the semiautomated high-throughput pipeline of the Joint Center for Structural Genomics (JCSG) as part of the NIGMS Protein Structure Initiative (PSI). The structures revealed a conserved core with domain duplication and a superfic...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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International Union of Crystallography
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954208/ https://www.ncbi.nlm.nih.gov/pubmed/20944214 http://dx.doi.org/10.1107/S1744309109050416 |
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| author | Han, Gye Won Bakolitsa, Constantina Miller, Mitchell D. Kumar, Abhinav Carlton, Dennis Najmanovich, Rafael J. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ernst, Dustin Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_facet | Han, Gye Won Bakolitsa, Constantina Miller, Mitchell D. Kumar, Abhinav Carlton, Dennis Najmanovich, Rafael J. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ernst, Dustin Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_sort | Han, Gye Won |
| collection | PubMed |
| description | The crystal structures of SPO0140 and Sbal_2486 were determined using the semiautomated high-throughput pipeline of the Joint Center for Structural Genomics (JCSG) as part of the NIGMS Protein Structure Initiative (PSI). The structures revealed a conserved core with domain duplication and a superficial similarity of the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain interface indicates a potential binding site that is likely to involve a nucleotide-based ligand, with genome-context and gene-fusion analyses additionally supporting a role for this family in signal transduction, possibly during oxidative stress. |
| format | Text |
| id | pubmed-2954208 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29542082010-10-27 Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction Han, Gye Won Bakolitsa, Constantina Miller, Mitchell D. Kumar, Abhinav Carlton, Dennis Najmanovich, Rafael J. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ernst, Dustin Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun New Folds The crystal structures of SPO0140 and Sbal_2486 were determined using the semiautomated high-throughput pipeline of the Joint Center for Structural Genomics (JCSG) as part of the NIGMS Protein Structure Initiative (PSI). The structures revealed a conserved core with domain duplication and a superficial similarity of the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain interface indicates a potential binding site that is likely to involve a nucleotide-based ligand, with genome-context and gene-fusion analyses additionally supporting a role for this family in signal transduction, possibly during oxidative stress. International Union of Crystallography 2010-03-05 /pmc/articles/PMC2954208/ /pubmed/20944214 http://dx.doi.org/10.1107/S1744309109050416 Text en © Han et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | New Folds Han, Gye Won Bakolitsa, Constantina Miller, Mitchell D. Kumar, Abhinav Carlton, Dennis Najmanovich, Rafael J. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ernst, Dustin Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Jaroszewski, Lukasz Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Marciano, David McMullan, Daniel Morse, Andrew T. Nigoghossian, Edward Okach, Linda Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Xu, Qingping Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction |
| title | Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction |
| title_full | Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction |
| title_fullStr | Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction |
| title_full_unstemmed | Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction |
| title_short | Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction |
| title_sort | structures of the first representatives of pfam family pf06938 (duf1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction |
| topic | New Folds |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954208/ https://www.ncbi.nlm.nih.gov/pubmed/20944214 http://dx.doi.org/10.1107/S1744309109050416 |
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