The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold

KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the...

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Detalles Bibliográficos
Autores principales: Das, Debanu, Kozbial, Piotr, Han, Gye Won, Carlton, Dennis, Jaroszewski, Lukasz, Abdubek, Polat, Astakhova, Tamara, Axelrod, Herbert L., Bakolitsa, Constantina, Chen, Connie, Chiu, Hsiu-Ju, Chiu, Michelle, Clayton, Thomas, Deller, Marc C., Duan, Lian, Ellrott, Kyle, Elsliger, Marc-André, Ernst, Dustin, Farr, Carol L., Feuerhelm, Julie, Grzechnik, Anna, Grant, Joanna C., Jin, Kevin K., Johnson, Hope A., Klock, Heath E., Knuth, Mark W., Krishna, S. Sri, Kumar, Abhinav, Marciano, David, McMullan, Daniel, Miller, Mitchell D., Morse, Andrew T., Nigoghossian, Edward, Nopakun, Amanda, Okach, Linda, Oommachen, Silvya, Paulsen, Jessica, Puckett, Christina, Reyes, Ron, Rife, Christopher L., Sefcovic, Natasha, Tien, Henry J., Trame, Christine B., van den Bedem, Henry, Weekes, Dana, Wooten, Tiffany, Xu, Qingping, Hodgson, Keith O., Wooley, John, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Wilson, Ian A.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Novel Variants of Known Folds and Function
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954213/
https://www.ncbi.nlm.nih.gov/pubmed/20944219
http://dx.doi.org/10.1107/S1744309109018168
Descripción
Sumario:KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family.

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