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The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold
KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954213/ https://www.ncbi.nlm.nih.gov/pubmed/20944219 http://dx.doi.org/10.1107/S1744309109018168 |
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| author | Das, Debanu Kozbial, Piotr Han, Gye Won Carlton, Dennis Jaroszewski, Lukasz Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Bakolitsa, Constantina Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Elsliger, Marc-André Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grant, Joanna C. Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Krishna, S. Sri Kumar, Abhinav Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_facet | Das, Debanu Kozbial, Piotr Han, Gye Won Carlton, Dennis Jaroszewski, Lukasz Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Bakolitsa, Constantina Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Elsliger, Marc-André Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grant, Joanna C. Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Krishna, S. Sri Kumar, Abhinav Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_sort | Das, Debanu |
| collection | PubMed |
| description | KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family. |
| format | Text |
| id | pubmed-2954213 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29542132010-10-27 The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold Das, Debanu Kozbial, Piotr Han, Gye Won Carlton, Dennis Jaroszewski, Lukasz Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Bakolitsa, Constantina Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Elsliger, Marc-André Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grant, Joanna C. Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Krishna, S. Sri Kumar, Abhinav Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun Novel Variants of Known Folds and Function KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family. International Union of Crystallography 2009-10-27 /pmc/articles/PMC2954213/ /pubmed/20944219 http://dx.doi.org/10.1107/S1744309109018168 Text en © Das et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Novel Variants of Known Folds and Function Das, Debanu Kozbial, Piotr Han, Gye Won Carlton, Dennis Jaroszewski, Lukasz Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Bakolitsa, Constantina Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C. Duan, Lian Ellrott, Kyle Elsliger, Marc-André Ernst, Dustin Farr, Carol L. Feuerhelm, Julie Grzechnik, Anna Grant, Joanna C. Jin, Kevin K. Johnson, Hope A. Klock, Heath E. Knuth, Mark W. Krishna, S. Sri Kumar, Abhinav Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Oommachen, Silvya Paulsen, Jessica Puckett, Christina Reyes, Ron Rife, Christopher L. Sefcovic, Natasha Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Hodgson, Keith O. Wooley, John Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold |
| title | The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold |
| title_full | The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold |
| title_fullStr | The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold |
| title_full_unstemmed | The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold |
| title_short | The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold |
| title_sort | structure of kpn03535 (gi|152972051), a novel putative lipoprotein from klebsiella pneumoniae, reveals an ob-fold |
| topic | Novel Variants of Known Folds and Function |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954213/ https://www.ncbi.nlm.nih.gov/pubmed/20944219 http://dx.doi.org/10.1107/S1744309109018168 |
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