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Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules
The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954216/ https://www.ncbi.nlm.nih.gov/pubmed/20944222 http://dx.doi.org/10.1107/S1744309110032999 |
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| author | Bakolitsa, Constantina Xu, Qingping Rife, Christopher L. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ellrott, Kyle Farr, Carol L. Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Kumar, Abhinav Lam, Winnie W. Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_facet | Bakolitsa, Constantina Xu, Qingping Rife, Christopher L. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ellrott, Kyle Farr, Carol L. Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Kumar, Abhinav Lam, Winnie W. Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. |
| author_sort | Bakolitsa, Constantina |
| collection | PubMed |
| description | The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex. |
| format | Text |
| id | pubmed-2954216 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29542162010-10-27 Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules Bakolitsa, Constantina Xu, Qingping Rife, Christopher L. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ellrott, Kyle Farr, Carol L. Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Kumar, Abhinav Lam, Winnie W. Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Acta Crystallogr Sect F Struct Biol Cryst Commun Human Gut Microbiome The crystal structure of the Bacteroides thetaiotaomicron protein BT_3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT_3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT_3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex. International Union of Crystallography 2010-09-22 /pmc/articles/PMC2954216/ /pubmed/20944222 http://dx.doi.org/10.1107/S1744309110032999 Text en © Bakolitsa et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Human Gut Microbiome Bakolitsa, Constantina Xu, Qingping Rife, Christopher L. Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L. Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Clayton, Thomas Das, Debanu Deller, Marc C. Duan, Lian Ellrott, Kyle Farr, Carol L. Feuerhelm, Julie Grant, Joanna C. Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K. Klock, Heath E. Knuth, Mark W. Kozbial, Piotr Krishna, S. Sri Kumar, Abhinav Lam, Winnie W. Marciano, David McMullan, Daniel Miller, Mitchell D. Morse, Andrew T. Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J. Trame, Christine B. van den Bedem, Henry Weekes, Dana Hodgson, Keith O. Wooley, John Elsliger, Marc-André Deacon, Ashley M. Godzik, Adam Lesley, Scott A. Wilson, Ian A. Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules |
| title | Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules |
| title_full | Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules |
| title_fullStr | Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules |
| title_full_unstemmed | Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules |
| title_short | Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules |
| title_sort | structure of bt_3984, a member of the susd/ragb family of nutrient-binding molecules |
| topic | Human Gut Microbiome |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954216/ https://www.ncbi.nlm.nih.gov/pubmed/20944222 http://dx.doi.org/10.1107/S1744309110032999 |
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