Ligands in crystal structures that aid in functional characterization

Liganded structures can be instrumental in assigning function to uncharacterized proteins by revealing active sites, conserved residues, binding motifs, and substrate specificity. This introduction provides an overview and commentary on the value of liganded structures emerging from the JCSG structu...

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Detalles Bibliográficos
Autores principales: Speers, Anna E., Cravatt, Benjamin F.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Ligands That Aid in Function Characterization
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954220/
https://www.ncbi.nlm.nih.gov/pubmed/20944226
http://dx.doi.org/10.1107/S1744309110035748
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author Speers, Anna E.
Cravatt, Benjamin F.
author_facet Speers, Anna E.
Cravatt, Benjamin F.
author_sort Speers, Anna E.
collection PubMed
description Liganded structures can be instrumental in assigning function to uncharacterized proteins by revealing active sites, conserved residues, binding motifs, and substrate specificity. This introduction provides an overview and commentary on the value of liganded structures emerging from the JCSG structural genomics initiative.
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spelling pubmed-29542202010-10-27 Ligands in crystal structures that aid in functional characterization Speers, Anna E. Cravatt, Benjamin F. Acta Crystallogr Sect F Struct Biol Cryst Commun Ligands That Aid in Function Characterization Liganded structures can be instrumental in assigning function to uncharacterized proteins by revealing active sites, conserved residues, binding motifs, and substrate specificity. This introduction provides an overview and commentary on the value of liganded structures emerging from the JCSG structural genomics initiative. International Union of Crystallography 2010-09-30 /pmc/articles/PMC2954220/ /pubmed/20944226 http://dx.doi.org/10.1107/S1744309110035748 Text en © Speers & Cravatt 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Ligands That Aid in Function Characterization
Speers, Anna E.
Cravatt, Benjamin F.
Ligands in crystal structures that aid in functional characterization
title Ligands in crystal structures that aid in functional characterization
title_full Ligands in crystal structures that aid in functional characterization
title_fullStr Ligands in crystal structures that aid in functional characterization
title_full_unstemmed Ligands in crystal structures that aid in functional characterization
title_short Ligands in crystal structures that aid in functional characterization
title_sort ligands in crystal structures that aid in functional characterization
topic Ligands That Aid in Function Characterization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954220/
https://www.ncbi.nlm.nih.gov/pubmed/20944226
http://dx.doi.org/10.1107/S1744309110035748
work_keys_str_mv AT speersannae ligandsincrystalstructuresthataidinfunctionalcharacterization
AT cravattbenjaminf ligandsincrystalstructuresthataidinfunctionalcharacterization

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