Ligands in PSI structures

Approximately 65% of PSI structures report some type of ligand(s) that is bound in the crystal structure. Here, a description is given of how such ligands are handled and analyzed at the JCSG and a survey of the types, variety and frequency of ligands that are observed in the PSI structures is also...

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Autores principales: Kumar, Abhinav, Chiu, Hsiu-Ju, Axelrod, Herbert L., Morse, Andrew, Elsliger, Marc-André, Wilson, Ian A., Deacon, Ashley
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Ligands That Aid in Function Characterization
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954221/
https://www.ncbi.nlm.nih.gov/pubmed/20944227
http://dx.doi.org/10.1107/S1744309110008092
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author Kumar, Abhinav
Chiu, Hsiu-Ju
Axelrod, Herbert L.
Morse, Andrew
Elsliger, Marc-André
Wilson, Ian A.
Deacon, Ashley
author_facet Kumar, Abhinav
Chiu, Hsiu-Ju
Axelrod, Herbert L.
Morse, Andrew
Elsliger, Marc-André
Wilson, Ian A.
Deacon, Ashley
author_sort Kumar, Abhinav
collection PubMed
description Approximately 65% of PSI structures report some type of ligand(s) that is bound in the crystal structure. Here, a description is given of how such ligands are handled and analyzed at the JCSG and a survey of the types, variety and frequency of ligands that are observed in the PSI structures is also compiled and analyzed, including illustrations of how these bound ligands have provided functional clues for annotation of proteins with little or no previous experimental characterization. Furthermore, a web server was developed as a tool to mine and analyze the PSI structures for bound ligands and other identifying features.
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spelling pubmed-29542212010-10-27 Ligands in PSI structures Kumar, Abhinav Chiu, Hsiu-Ju Axelrod, Herbert L. Morse, Andrew Elsliger, Marc-André Wilson, Ian A. Deacon, Ashley Acta Crystallogr Sect F Struct Biol Cryst Commun Ligands That Aid in Function Characterization Approximately 65% of PSI structures report some type of ligand(s) that is bound in the crystal structure. Here, a description is given of how such ligands are handled and analyzed at the JCSG and a survey of the types, variety and frequency of ligands that are observed in the PSI structures is also compiled and analyzed, including illustrations of how these bound ligands have provided functional clues for annotation of proteins with little or no previous experimental characterization. Furthermore, a web server was developed as a tool to mine and analyze the PSI structures for bound ligands and other identifying features. International Union of Crystallography 2010-07-06 /pmc/articles/PMC2954221/ /pubmed/20944227 http://dx.doi.org/10.1107/S1744309110008092 Text en © Kumar et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Ligands That Aid in Function Characterization
Kumar, Abhinav
Chiu, Hsiu-Ju
Axelrod, Herbert L.
Morse, Andrew
Elsliger, Marc-André
Wilson, Ian A.
Deacon, Ashley
Ligands in PSI structures
title Ligands in PSI structures
title_full Ligands in PSI structures
title_fullStr Ligands in PSI structures
title_full_unstemmed Ligands in PSI structures
title_short Ligands in PSI structures
title_sort ligands in psi structures
topic Ligands That Aid in Function Characterization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954221/
https://www.ncbi.nlm.nih.gov/pubmed/20944227
http://dx.doi.org/10.1107/S1744309110008092
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AT morseandrew ligandsinpsistructures
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AT wilsoniana ligandsinpsistructures
AT deaconashley ligandsinpsistructures

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