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Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

To probe increased O-GlcNAc levels as an independent mechanism governing insulin resistance in 3T3-L1 adipocytes, a new class of O-GlcNAcase (OGA) inhibitor was studied. 6-Acetamido-6-deoxy-castanospermine (6-Ac-Cas) is a potent inhibitor of OGA. The structure of 6-Ac-Cas bound in the active site of...

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Detalles Bibliográficos
Autores principales:	Macauley, Matthew S., He, Yuan, Gloster, Tracey M., Stubbs, Keith A., Davies, Gideon J., Vocadlo, David J.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954295/ https://www.ncbi.nlm.nih.gov/pubmed/20851343 http://dx.doi.org/10.1016/j.chembiol.2010.07.006

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