A CLINICAL GENETIC STUDY OF ADULT OBSESSIVE COMPULSIVE DISORDER FROM INDIA

OBJECTIVE: The current study aims to replicate western reports of a familial excess of syndromal and sub-syndromal Obsessive Compulsive Disorder (OCD) in OCD probands in an Indian population. METHOD: 148 relatives of OCD probands were compared with 151 normal subjects, based on evaluation on Schedule for Clinical Assessment for Neuropsychiatry (SCAN). RESULTS: There were no clinically significant differences in the prevalence of psychiatric disorders between the two samples. CONCLUSION: In an Indian setting, the absence of familial loading in adult OCD is being reported. Whether subgroups of OCD are familial, or other factors play a role in the pathogenesis of OCD in India needs to be explored.