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Human Blood Concentrations of Cotinine, a Biomonitoring Marker for Tobacco Smoke, Extrapolated from Nicotine Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling

The present study defined a simplified physiologically based pharmacokinetic (PBPK) model for nicotine and its primary metabolite cotinine in humans, based on metabolic parameters determined in vitro using relevant liver microsomes, coefficients derived in silico, physiological parameters derived fr...

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Detalles Bibliográficos
Autores principales:	Yamazaki, Hiroshi, Horiuchi, Kana, Takano, Ryohji, Nagano, Taku, Shimizu, Makiko, Kitajima, Masato, Murayama, Norie, Shono, Fumiaki
Formato:	Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954553/ https://www.ncbi.nlm.nih.gov/pubmed/20948932 http://dx.doi.org/10.3390/ijerph7093406

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