Cargando…

Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus

BACKGROUND: Gene profiling studies provide important information for key molecules relevant to a disease but are less informative of protein-protein interactions, post-translational modifications and regulation by targeted subcellular localization. Integration of genomic data and construction of fun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakou, Magdalene, Bertsias, George, Stagakis, Ilias, Centola, Michael, Tassiulas, Ioannis, Hatziapostolou, Maria, Kritikos, Iraklis, Goulielmos, George, Boumpas, Dimitrios T., Iliopoulos, Dimitrios
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954787/ https://www.ncbi.nlm.nih.gov/pubmed/20976278 http://dx.doi.org/10.1371/journal.pone.0013351

Ejemplares similares

Correction: Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus
por: Nakou, Magdalene, et al.
Publicado: (2013)

TLR-9, but not TLR-2, TLR-3 and TLR-4, is upregulated on peripheral blood mononuclear cells of patients with active systemic lupus erythematosus
por: Papadimitraki, ED, et al.
Publicado: (2005)

Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response
por: Nakou, Magda, et al.
Publicado: (2009)

Expression of programmed death (PD)-1 and PD-1 ligands (PD-L1, PD-L2) in peripheral blood mononuclear cells of patients with systemic lupus erythematosus
por: Bertsias, G, et al.
Publicado: (2005)

Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance
por: Stagakis, Ilias, et al.
Publicado: (2012)

Extensive fragmentation and re-organization of transcription in Systemic Lupus Erythematosus
por: Ntasis, Vasilis F., et al.
Publicado: (2020)

Molecular Taxonomy of Systemic Lupus Erythematosus Through Data-Driven Patient Stratification: Molecular Endotypes and Cluster-Tailored Drugs
por: Garantziotis, Panagiotis, et al.
Publicado: (2022)

Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy
por: Nikolakis, Dimitrios, et al.
Publicado: (2023)

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus
por: Grigoriou, Maria, et al.
Publicado: (2020)

The genomic landscape of ANCA-associated vasculitis: Distinct transcriptional signatures, molecular endotypes and comparison with systemic lupus erythematosus
por: Banos, Aggelos, et al.
Publicado: (2023)

Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine learning-based model to assist the diagnosis of systemic lupus erythematosus
por: Adamichou, Christina, et al.
Publicado: (2021)

Advances in Systemic Lupus Erythematosus (SLE): A case for optimism
por: Fanouriakis, Antonis, et al.
Publicado: (2017)

Epione application: An integrated web-toolkit of clinical genomics and personalized medicine in systemic lupus erythematosus
por: Papageorgiou, Louis, et al.
Publicado: (2022)

Cerebrovascular Events in Systemic Lupus Erythematosus: Diagnosis and Management
por: Nikolopoulos, Dionysis, et al.
Publicado: (2019)

Genetic Variation near IRF8 is Associated with Serologic and Cytokine Profiles in Systemic Lupus Erythematosus and Multiple Sclerosis
por: Chrabot, Beverly S., et al.
Publicado: (2013)

Progressive Multifocal Leukoencephalopathy in Systemic Lupus Erythematosus: A Consequence of Patient-Intrinsic or -Extrinsic Factors?
por: Emmanouilidou, Evgenia, et al.
Publicado: (2023)

Development and Implementation of a Pilot Registry for Monitoring the Efficacy and Safety of Novel Therapies in Patients with Systemic Lupus Erythematosus
por: Adamichou, Christina, et al.
Publicado: (2020)

Changing paradigms in the treatment of systemic lupus erythematosus
por: Fanouriakis, Antonis, et al.
Publicado: (2019)

Editorial: Lupus and the Brain: Advances in Neuropsychiatric Systemic Lupus Erythematosus
por: Fanouriakis, Antonis, et al.
Publicado: (2019)

Clinical response trajectories and drug persistence in systemic lupus erythematosus patients on belimumab treatment: A real-life, multicentre observational study
por: Nikoloudaki, Myrto, et al.
Publicado: (2023)

Heart failure with complete recovery in a patient with systemic lupus erythematosus
por: Lampropoulos, Konstantinos, et al.
Publicado: (2015)

Flares in systemic lupus erythematosus: diagnosis, risk factors and preventive strategies
por: Adamichou, Christina, et al.
Publicado: (2017)

Deciphering the Molecular Mechanism of Flares in Patients with Systemic Lupus Erythematosus through Single-Cell Transcriptome Analysis of the Peripheral Blood
por: Papanikolaou, Sofia, et al.
Publicado: (2022)

Demyelinating Syndromes in Systemic Lupus Erythematosus: Data From the “Attikon” Lupus Cohort
por: Nikolopoulos, Dionysis, et al.
Publicado: (2022)

Microglia activation in the presence of intact blood–brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus
por: Nikolopoulos, Dionysis, et al.
Publicado: (2023)

Systemic Lupus Erythematosus in Primary Care: An Update and Practical Messages for the General Practitioner
por: Gergianaki, Irini, et al.
Publicado: (2018)

Management of lupus nephritis: a systematic literature review informing the 2019 update of the joint EULAR and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations
por: Kostopoulou, Myrto, et al.
Publicado: (2020)

Investigating the Role of T-bet(+) B Cells (ABCs/DN) in the Immunopathogenesis of Systemic Lupus Erythematosus
por: Sachinidis, Athanasios, et al.
Publicado: (2023)

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)
por: Frangou, Eleni, et al.
Publicado: (2019)

ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus
por: Manolakou, Theodora, et al.
Publicado: (2022)

Treating systemic lupus erythematosus in the 21st century: new drugs and new perspectives on old drugs
por: Ruiz-Irastorza, Guillermo, et al.
Publicado: (2020)

Altered hippocampal connectivity dynamics predicts memory performance in neuropsychiatric lupus: a resting-state fMRI study using cross-recurrence quantification analysis
por: Pentari, Anastasia, et al.
Publicado: (2023)

Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent
por: Alunno, Alessia, et al.
Publicado: (2019)

Extensive Changes in Transcription Dynamics Reflected on Alternative Splicing Events in Systemic Lupus Erythematosus Patients
por: Papanikolaou, Sofia, et al.
Publicado: (2021)

Birth Registry of Women With Systematic Lupus Erythematosus: The Greek Experience
por: Ntali, Stella, et al.
Publicado: (2018)

Real-Life Outcome of Lupus Nephritis with Current Therapies: Study Protocol of a Multicentre Observational Study
por: Pappa, Maria, et al.
Publicado: (2022)

A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma
por: Palumbo, Tiziana, et al.
Publicado: (2016)

Sexual dysfunction among women with systemic lupus erythematosus: might it reflect cardiovascular disease burden?
por: Patoulias, Dimitrios Ioannis
Publicado: (2019)

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway
por: Drakaki, Alexandra, et al.
Publicado: (2015)

Transition to severe phenotype in systemic lupus erythematosus initially presenting with non-severe disease: implications for the management of early disease
por: Nikolopoulos, Dionysis S, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g37d2khqkq3lt18b843hspmcre