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Evolution of a Signaling Nexus Constrained by Protein Interfaces and Conformational States

Heterotrimeric G proteins act as the physical nexus between numerous receptors that respond to extracellular signals and proteins that drive the cytoplasmic response. The Gα subunit of the G protein, in particular, is highly constrained due to its many interactions with proteins that control or reac...

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Detalles Bibliográficos
Autores principales:	Temple, Brenda R. S., Jones, Corbin D., Jones, Alan M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954821/ https://www.ncbi.nlm.nih.gov/pubmed/20976244 http://dx.doi.org/10.1371/journal.pcbi.1000962

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