Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

A remarkable characteristic of the human major histocompatibility complex (MHC) is its extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC complex remains one of the best-known examples of natural selection in humans, with well-established genetic signatures and b...

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Detalles Bibliográficos
Autores principales: Andrés, Aida M., Dennis, Megan Y., Kretzschmar, Warren W., Cannons, Jennifer L., Lee-Lin, Shih-Queen, Hurle, Belen, Schwartzberg, Pamela L., Williamson, Scott H., Bustamante, Carlos D., Nielsen, Rasmus, Clark, Andrew G., Green, Eric D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954825/
https://www.ncbi.nlm.nih.gov/pubmed/20976248
http://dx.doi.org/10.1371/journal.pgen.1001157

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