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Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite Metalloprotease GP63
Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-κB. AP-1 regulates pro-inflammatory cytokin...
Autores principales: | Contreras, Irazú, Gómez, María Adelaida, Nguyen, Oliver, Shio, Marina T., McMaster, Robert W., Olivier, Martin |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954837/ https://www.ncbi.nlm.nih.gov/pubmed/20976196 http://dx.doi.org/10.1371/journal.ppat.1001148 |
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