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Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell

As one of the disciplines of systems biology, proteomics is central to enabling the elucidation of protein function within the cell; furthermore, the question of how to deduce protein structure and function from the genetic readout has gained new significance. This problem is of particular relevance...

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Autor principal: Helmreich, Ernst JM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954850/
https://www.ncbi.nlm.nih.gov/pubmed/20849616
http://dx.doi.org/10.1186/1478-811X-8-26
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author Helmreich, Ernst JM
author_facet Helmreich, Ernst JM
author_sort Helmreich, Ernst JM
collection PubMed
description As one of the disciplines of systems biology, proteomics is central to enabling the elucidation of protein function within the cell; furthermore, the question of how to deduce protein structure and function from the genetic readout has gained new significance. This problem is of particular relevance for proteins engaged in cell signalling. In dealing with this question, I shall critically comment on the reliability and predictability of transmission and translation of the genetic blue print into the phenotype, the protein. Based on this information, I will then evaluate the intentions and goals of today's proteomics and gene-networking and appraise their chances of success. Some of the themes commented on in this publication are explored in greater detail with particular emphasis on the historical roots of concepts and techniques in my forthcoming book, published in German: Von Molekülen zu Zellen. 100 Jahre experimentelle Biologie. Betrachtungen eines Biochemikers.
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spelling pubmed-29548502010-10-15 Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell Helmreich, Ernst JM Cell Commun Signal Commentary As one of the disciplines of systems biology, proteomics is central to enabling the elucidation of protein function within the cell; furthermore, the question of how to deduce protein structure and function from the genetic readout has gained new significance. This problem is of particular relevance for proteins engaged in cell signalling. In dealing with this question, I shall critically comment on the reliability and predictability of transmission and translation of the genetic blue print into the phenotype, the protein. Based on this information, I will then evaluate the intentions and goals of today's proteomics and gene-networking and appraise their chances of success. Some of the themes commented on in this publication are explored in greater detail with particular emphasis on the historical roots of concepts and techniques in my forthcoming book, published in German: Von Molekülen zu Zellen. 100 Jahre experimentelle Biologie. Betrachtungen eines Biochemikers. BioMed Central 2010-09-17 /pmc/articles/PMC2954850/ /pubmed/20849616 http://dx.doi.org/10.1186/1478-811X-8-26 Text en Copyright ©2010 Helmreich; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Helmreich, Ernst JM
Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell
title Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell
title_full Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell
title_fullStr Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell
title_full_unstemmed Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell
title_short Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell
title_sort ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954850/
https://www.ncbi.nlm.nih.gov/pubmed/20849616
http://dx.doi.org/10.1186/1478-811X-8-26
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