Role of Wnt canonical pathway in hematological malignancies

Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas. Moreover, Wnt/β-catenin pathway has been revealed to be associa...

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Detalles Bibliográficos
Autores principales: GE, Xueling, Wang, Xin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954871/
https://www.ncbi.nlm.nih.gov/pubmed/20843302
http://dx.doi.org/10.1186/1756-8722-3-33
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author GE, Xueling
Wang, Xin
author_facet GE, Xueling
Wang, Xin
author_sort GE, Xueling
collection PubMed
description Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas. Moreover, Wnt/β-catenin pathway has been revealed to be associated with angiogenesis. Wnt canonical pathway signaling has great potential as a therapeutic target. It has been disclosed that some hematological malignancies, such as chronic lymphocytic leukemia, mantle cell lymphoma, may occur partly due to the constitutive activation of Wnt canonical signaling pathway. This review will summarize the latest development in Wnt canonical signaling pathway and its roles in tumorigenesis and angiogenesis.
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spelling pubmed-29548712010-10-15 Role of Wnt canonical pathway in hematological malignancies GE, Xueling Wang, Xin J Hematol Oncol Review Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas. Moreover, Wnt/β-catenin pathway has been revealed to be associated with angiogenesis. Wnt canonical pathway signaling has great potential as a therapeutic target. It has been disclosed that some hematological malignancies, such as chronic lymphocytic leukemia, mantle cell lymphoma, may occur partly due to the constitutive activation of Wnt canonical signaling pathway. This review will summarize the latest development in Wnt canonical signaling pathway and its roles in tumorigenesis and angiogenesis. BioMed Central 2010-09-15 /pmc/articles/PMC2954871/ /pubmed/20843302 http://dx.doi.org/10.1186/1756-8722-3-33 Text en Copyright ©2010 GE and Wang; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
GE, Xueling
Wang, Xin
Role of Wnt canonical pathway in hematological malignancies
title Role of Wnt canonical pathway in hematological malignancies
title_full Role of Wnt canonical pathway in hematological malignancies
title_fullStr Role of Wnt canonical pathway in hematological malignancies
title_full_unstemmed Role of Wnt canonical pathway in hematological malignancies
title_short Role of Wnt canonical pathway in hematological malignancies
title_sort role of wnt canonical pathway in hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954871/
https://www.ncbi.nlm.nih.gov/pubmed/20843302
http://dx.doi.org/10.1186/1756-8722-3-33
work_keys_str_mv AT gexueling roleofwntcanonicalpathwayinhematologicalmalignancies
AT wangxin roleofwntcanonicalpathwayinhematologicalmalignancies

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