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Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis
BACKGROUND: The mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene results in CF. The most common mutation, ΔF508-CFTR, is a temperature-sensitive, trafficking mutant with reduced chloride transport and exaggerated immune response. The ΔF508-CFTR is misfolded, ubiquitina...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954907/ https://www.ncbi.nlm.nih.gov/pubmed/20868490 http://dx.doi.org/10.1186/1477-3155-8-22 |