Inhibition of the Striatal Specific Phosphodiesterase PDE10A Ameliorates Striatal and Cortical Pathology in R6/2 Mouse Model of Huntington's Disease

BACKGROUND: Huntington's disease is a devastating neurodegenerative condition for which there is no therapy to slow disease progression. The particular vulnerability of striatal medium spiny neurons to Huntington's pathology is hypothesized to result from transcriptional dysregulation with...

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Detalles Bibliográficos
Autores principales: Giampà, Carmela, Laurenti, Daunia, Anzilotti, Serenella, Bernardi, Giorgio, Menniti, Frank S., Fusco, Francesca Romana
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955524/
https://www.ncbi.nlm.nih.gov/pubmed/20976216
http://dx.doi.org/10.1371/journal.pone.0013417

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