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Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model

BACKGROUND: Polymorphonuclear neutrophils, stimulated by the activated complement factor C5a, have been implicated in cardiac ischemia/reperfusion injury. ADC-1004 is a competitive C5a receptor antagonist that has been shown to inhibit complement related neutrophil activation. ADC-1004 shields the n...

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Detalles Bibliográficos
Autores principales:	van der Pals, Jesper, Koul, Sasha, Andersson, Patrik, Götberg, Matthias, Ubachs, Joey FA, Kanski, Mikael, Arheden, Håkan, Olivecrona, Göran K, Larsson, Bengt, Erlinge, David
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955599/ https://www.ncbi.nlm.nih.gov/pubmed/20875134 http://dx.doi.org/10.1186/1471-2261-10-45

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