MicroRNA roles in beta-catenin pathway

β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt sig...

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Detalles Bibliográficos
Autores principales: Huang, Kai, Zhang, Jun-Xia, Han, Lei, You, Yong-Ping, Jiang, Tao, Pu, Pei-Yu, Kang, Chun-Sheng
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955614/
https://www.ncbi.nlm.nih.gov/pubmed/20858269
http://dx.doi.org/10.1186/1476-4598-9-252
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author Huang, Kai
Zhang, Jun-Xia
Han, Lei
You, Yong-Ping
Jiang, Tao
Pu, Pei-Yu
Kang, Chun-Sheng
author_facet Huang, Kai
Zhang, Jun-Xia
Han, Lei
You, Yong-Ping
Jiang, Tao
Pu, Pei-Yu
Kang, Chun-Sheng
author_sort Huang, Kai
collection PubMed
description β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.
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spelling pubmed-29556142010-10-16 MicroRNA roles in beta-catenin pathway Huang, Kai Zhang, Jun-Xia Han, Lei You, Yong-Ping Jiang, Tao Pu, Pei-Yu Kang, Chun-Sheng Mol Cancer Review β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment. BioMed Central 2010-09-21 /pmc/articles/PMC2955614/ /pubmed/20858269 http://dx.doi.org/10.1186/1476-4598-9-252 Text en Copyright ©2010 Huang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Huang, Kai
Zhang, Jun-Xia
Han, Lei
You, Yong-Ping
Jiang, Tao
Pu, Pei-Yu
Kang, Chun-Sheng
MicroRNA roles in beta-catenin pathway
title MicroRNA roles in beta-catenin pathway
title_full MicroRNA roles in beta-catenin pathway
title_fullStr MicroRNA roles in beta-catenin pathway
title_full_unstemmed MicroRNA roles in beta-catenin pathway
title_short MicroRNA roles in beta-catenin pathway
title_sort microrna roles in beta-catenin pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955614/
https://www.ncbi.nlm.nih.gov/pubmed/20858269
http://dx.doi.org/10.1186/1476-4598-9-252
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AT hanlei micrornarolesinbetacateninpathway
AT youyongping micrornarolesinbetacateninpathway
AT jiangtao micrornarolesinbetacateninpathway
AT pupeiyu micrornarolesinbetacateninpathway
AT kangchunsheng micrornarolesinbetacateninpathway

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