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Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition

BACKGROUND: Dysregulation of epidermal growth factor and insulin-like growth factor signaling play important roles in human hepatocellular carcinoma (HCC), leading to frequent activation of their downstream targets, the ras/raf/extracellular signal-regulated kinase (ERK) and the phosphoinositide 3-k...

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Detalles Bibliográficos
Autores principales:	Charette, Nicolas, De Saeger, Christine, Lannoy, Valérie, Horsmans, Yves, Leclercq, Isabelle, Stärkel, Peter
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955616/ https://www.ncbi.nlm.nih.gov/pubmed/20860815 http://dx.doi.org/10.1186/1476-4598-9-256

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