Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression

BACKGROUND: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; apo2 ligand) induces apoptosis in cancer cells but has little effect on normal cells. However, many cancer cell types are resistant to TRAIL-induced apoptosis, limiting the clinical utility of TRAIL as an anti-cancer a...

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Detalles Bibliográficos
Autores principales: Jang, Ji-Young, Jeon, Yoon-Kyung, Choi, Yun, Kim, Chul-Woo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955620/
https://www.ncbi.nlm.nih.gov/pubmed/20875141
http://dx.doi.org/10.1186/1476-4598-9-262

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