Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells

BACKGROUND: Stearoyl-CoA desaturase 1 (SCD1) is an ER resident enzyme introducing a double-bond in saturated fatty acids. Global knockout of SCD1 in mouse increases fatty acid oxidation and insulin sensitivity which makes the animal resistant to diet-induced obesity. Inhibition of SCD1 has therefore...

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Detalles Bibliográficos
Autores principales: Thörn, Kristofer, Hovsepyan, Meri, Bergsten, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955640/
https://www.ncbi.nlm.nih.gov/pubmed/20920255
http://dx.doi.org/10.1186/1476-511X-9-108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955640/
https://www.ncbi.nlm.nih.gov/pubmed/20920255
http://dx.doi.org/10.1186/1476-511X-9-108

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