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Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells
BACKGROUND: Stearoyl-CoA desaturase 1 (SCD1) is an ER resident enzyme introducing a double-bond in saturated fatty acids. Global knockout of SCD1 in mouse increases fatty acid oxidation and insulin sensitivity which makes the animal resistant to diet-induced obesity. Inhibition of SCD1 has therefore...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955640/ https://www.ncbi.nlm.nih.gov/pubmed/20920255 http://dx.doi.org/10.1186/1476-511X-9-108 |