Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

BACKGROUND: Mutations in presenilin-1 (Psen1) cause familial Alzheimer's disease (FAD). Both hypoxia and ischemia have been implicated in the pathological cascade that leads to amyloid deposition in AD. Here we investigated whether Psen1 might regulate hypoxic responses by modulating induction...

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Detalles Bibliográficos
Autores principales: De Gasperi, Rita, Sosa, Miguel A Gama, Dracheva, Stella, Elder, Gregory A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955646/
https://www.ncbi.nlm.nih.gov/pubmed/20863403
http://dx.doi.org/10.1186/1750-1326-5-38

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